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The 15th International Conference on Density Functional Theory and its Applications (DFT2013) took place in the Calman Learning Centre and Earth Science Rooms in Durham, from 09-13 September 2013. This is the latest in a series of biennial conferences, which have taken place most recently in Brussels, Geneva, Amsterdam, Lyon, and Athens. The conference was attended by 220 participants from more than 35 countries, with 28 lectures and 165 poster presentations, on topics ranging from fundamental theory development to applications in chemistry, physics, biology, and materials science.