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The annual international conference on Intelligent Systems for Molecular Biology (ISMB) is the flagship meeting of the International Society for Computational Biology (ISCB). The 2019 conference is the 27th ISMB conference and has grown to become the world's largest bioinformatics/computational biology conference. Joining forces with the European Conference on Computational Biology (18th Annual Conference) ISMB/ECCB 2019, July 21-25, at the Basel Congress Centre, will be the year's most important computational biology event globally. ISMB/ECCB brings together scientists from computer science, molecular biology, mathematics, statistics and related fields. Its principal focus is on the development and application of advanced computational methods for biological problems.