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ISBA 15th conference, held from August 20–25th, 2009 at the Shanghai International Convention Centre. More than 600 scientists from 40 different countries attended. 10 Plenary lectures and nine concurrent sessions, namely Biological insights from omics; Natural products and biosynthesis; Systematics and diversity; Morphological differentiation; Actinomycetes-related biotechnology and bioengineering; Pathogenic actinomycetes; Combinatorial biosynthesis and pathway engineering; Physiology and genetics; Regulatory networks and Actinomycetes and environment.