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SSC conference is organized each second year in Moscow – the largest European megapolis. SSC conference is a traditional discussion platform for a broad audience, including scientific and research community, municipal services, environmental protection agencies and stakeholders working in architecture, landscape design, development and maintenance of urban green infrastructures. SSC-2022 will remain and strengthen the developed interdisciplinary status of the meeting. It will address the current challenges for sustainable urban development, including pollution, climate change and health risks with especial focus on the impact and consequences of COVID-19. A particular focus will be given to solutions aiming to reach sustainability: climate adaptation measures, smart technologies to monitor and manage urban soils and green infrastructures and nature-based solutions This year’s theme for the conference will be «Sustainable urban ecosystems: challenges and solutions». Megapolises are complex ecosystems. Air and water quality, vegetation and soils in megapolises are exposed to anthropogenic influence. Studying negative environmental consequences of the anthropogenic and technogenic pressures is among the key tasks of urban ecology and environmental impact assessment. Advanced approaches and smart technologies to monitor, model and assess environmental consequences and risks in megapolises will be widely discussed at the conference. Successful experiences of sustainable urban development and nature-based solutions to support climate adaptation, carbon neutrality and human health will be presented.