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AESC one of Lomonosov Moscow State University subdivisions established in 1963 by Acad. A.N. Kolmogorov. The Chemistry division of AESC is 25-years old. In 2003 started a new class focusing on life sciences with the project-based learning implemented in education program. Later students of early-created advanced chemistry class were involved into the projects activity. It was stimulated by the fact, that our students have good theoretical basis and enough practical activity, but competence skills in the field of modern analytical methods are insufficient. The realised solution is to encourage the students to research under qualified supervising in scientific labs. Since more than 130 research projects have done. The project activity leads our students to get an experience of work with modern devices and techniques, improve their presentation skills and establish initial social communications in scientific world. The skills elaborated by project-based learning allow them to choose knowingly a way for further high education and to turn readily to scientific activity after admission in Universities.