ИСТИНА

Purpose: The aim of the present experiment was to evaluate the role of olfactory system in the generation of the spike-and-wave discharges (SWDs) in WAG/Rij rats. Method: Before surgery WAG/Rij rats were anesthetized by Nembutal in a dose of 47 mg/kg. EEG electrodes were chronically implanted into frontal cortex. The mean duration and number of SWDs were calculated. CONAN EEG recording software was used. The deafferentation of olfactory bulbs was induced by i.p. injection of the olfactory epithelial toxin 3- methyl indole (3 MI) in a dose of 200 mg/kg. Results: Significant increase in number of SWDs (p<0.01, by means of Wilcoxon matched pairs test) was found for the treatment group compared to the control rats. Analysis of duration of SWDs showed no significant effects. Conclusion: According to our results we can suggest that olfactory system is include to the mechanisms of generation of the SWDs. I.p. injection of the olfactory epithelial toxin 3-methyl indole (3 MI) induced the increase of the number of the SWDs.