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Water quality in surface water sources - rivers, lakes and reservoirs - is influenced by two main factors - natural and anthropogenic. Therefore, the solution of practical problems of forecasting and study methods to regulate water quality is only possible with a thorough knowledge of the laws of its formation in natural water bodies and their catchments. The only way to obtain this knowledge - geographical and hydrological studies of water bodies that allow us to establish patterns of spatial and temporal changes in water quality and to develop methods of prediction and control the sources of water supply. The report presents the results of geographical and hydrological studies of water supply system of the Moscow metropolis, as a result of which were obtained by assessing the transformation of organic substances of natural origin in the system of reservoirs, a forecast of water quality at the water objects, demonstrated the possibility of adjusting the water quality on the Upper Volga and the causes of abnormal oscillation water quality. Modeling of hydro-ecological status of basic water supply - water reservoirs - prepared a forecast of the process of eutrophication and ways to regulate the quality of water during periods of abnormal meteorological influences.