|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Mitochondrial ROS play a critical role in the major neutrophil functional responsesдоклад на конференции
- Авторы: Galkin I., Pletjushkina O., Zinovkin R., Prikhodko A., Pinegin B., Vorobjeva N., Chernyak B.
- Региональная Конференция (Семинар (workshop)) : Экологические и биологические системы, Москва, 24.05.2018
- Даты проведения конференции: 24 мая 2018
- Дата доклада: 24 мая 2018
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: Москва, Russia
-
Аннотация доклада:
We investigated a possible role of mitochondria-derived ROS (mtROS) in the regulation of neutrophil activation induced by chemoattractant fMLP in vitro. Using the mitochondria-targeted antioxidant SkQ1, we demonstrated that mtROS are implicated in the oxidative burst caused by NOX2 activation as well as in the exocytosis of primary (azurophil) and secondary (specific) granules. Scavenging of mtROS with SkQ1 slightly accelerated spontaneous apoptosis and significantly stimulated apoptosis of fMLP-activated neutrophils. These data indicate that mtROS play a critical role in signal transduction that mediates the major neutrophil functional responses in the process of activation.
- Добавил в систему: Воробьева Нина Викторовна