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Microfluidic rheological approach to study fibrinogen specific adsorption on human erythrocytes membraneдоклад на конференции
- Авторы: Semenov A.N., Priezzhev A.V., Muravyov A.V., Lugovtsov А.Е.
- Международная Конференция : 1st International School on HemoPhysics
- Даты проведения конференции: 15-18 мая 2018
- Дата доклада: 17 мая 2018
- Тип доклада: Стендовый
- Докладчик: Semenov A.N.
- Место проведения: Монпелье, France
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Аннотация доклада:
Plasma protein fibrinogen has been considered as a main proaggregant agent of erythrocytes in human blood while mechanisms of this process remain unclear. Adsorption of fibrinogen macromolecules on erythrocytes membrane may serve as a regulating factor of erythrocytes aggregation. Critical shear-stress (CSS) as a parameter of cells interaction strength in of fibrinogen-induced erythrocyte aggregation was measured at the presence of the membrane integrin glycoprotein IIb/IIIa inhibitor eptifibatide. We observed a 15-30% decrease of CSS depending on the concentration of the eptifibatide in the incubation solution.
- Добавил в систему: Семенов Алексей Николаевич