ИСТИНА

It is known that from 30 to 60 % of all diseases in agricultural crops is transferred through the seeds and the soil. Treatment of seed is one of the most eco-friendly ways of use of chemicals. For innovative integrated seed treatments, the mechanochemical method of obtaining molecular complexes of well known fungicide agent tebuconazole (TBK) was used. They consist from supramolecular complexes which form from natural organic substances, such as polysaccharide arabinogalactan and derivatives of natural saponin – glycyrrhizic acid. The dry compositions were prepared by milling in ball mill and include molecules of TBC as active drug. They were studied in solid phase and in solution by various physico - chemical methods. The formation of supramolecular structures and incorporation of TBC molecules into them were shown by increasing of intrinsic solubility of TBC, studying of solubility phase diagrams and 1H NMR relaxation technique in solutions of the compositions. The transport of TBC from solutions through the artificial membrane (PAMPA assay) and to the seeds was studied. The improving of absorption of TBK from its supramolecular systems has been shown. On the basis of the data, the optimal composition and conditions for the preparation of the compositions are justified. The obtained preparations were biologically tested in laboratory and field conditions and had shown high biological effectiveness against pathogenic micro flora in the treatment of spring wheat and barley seeds, the absence of a retardant effect and a positive impact on the productivity of these crops. The complex biological data, a composition superior to the widely used commercial drug RAXIL and reduce the flow rate/dose of FA to ~2 times were obtained.