ИСТИНА

The newest results of application areas and advantages of mechanochemical technology of drug modification are considered. The main approach for pharmacy is based on preparation of solid disperse systems of pharmaceutics’ substances with different auxiliaries – oligo- and polysaccharide, plant’s saponins, synthetic polymers, amorphous silica substances. After dissolution in water they form inclusion complexes, micelles and nanoparticles, which containing drug molecules. Noted processes provide sufficiently increasing of solubility, bioavailability and pharmacology action (lowering of meaning doses in 2-100 folds) of drug. There is briefly discussion the various designs of mill for mechanochemistry and recommendations for their use [1-6], for examples.