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Key words: fluorescence navigation, glioma, meningioma, metastases, 5aminolevulinic acid. Introduction: Intraoperative 5ALA fluorescence diagnostics is an effective method of neuronavigation used in neurooncology and in surgery of brain tumors of different histologic types. Objective: The research was aimed at studying the sensitivity of fluorescence diagnostics in different brain tumor histology. Material and methods: A group of 473 patients was enrolled in this study for the period from 2010 to 2017; of them glial tumors were diagnosed in 337 cases, meningiomas in 88 cases, and metastases in 48 cases. In all cases surgery was performed with operative «Carl Zeiss Pentero» microscope equipped with a fluorescence module. Fluorescence intensity was evaluated by visible observation results using the following gradation scale: 0 absence of fluorescence, 1 mild fluorescence, 2 moderate fluorescence, 3 bright fluorescence. In the analyzed group of patients 365 of 473 operations were performed under intraoperative neurophysiological monitoring. Functional status was evaluated by Karnofsky scale before surgery and on day 7 after it in all patients of this group. Results: Visible fluorescence was marked in 83,1% of patients with glial tumors (low grade gliomas were diagnosed in 43,1% of cases, highgrade gliomas in 89,1% of cases), in 93,18% of patients with meningiomas and in 87,5% of patients with metastatic brain tumors. Fluorescence intensity is demonstrated in the table. According to Karnofsky scale, 78 of 473 patients improved, 79 patients deteriorated, 316 patients retained preoperative functional status. Conclusion: 5ALAinduced fluorescence diagnostics is a sensitive and highly effective method of intraoperative neuronavigation for patients with high grade gliomas, meningiomas and metastases. Fluorescence diagnostics in low grade gliomas is less effective.