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Recently we have described the long-lasting suppression of the anxiety and decrease of depression-like behavior of albino rats after the active immunization against cholecystokinin fragment 30-33 (CCK-4). In the present work we describe that CCK-4 covalently linked to antigen-carrier evokes a long-lasting (at least for two months) suppression of alcohol motivation in voluntary rats and creates a positive effect on the psychoemotional status of alcoholized rats after the ethanol deprivation period. The results also highlight the therapeutic potential of active immunization against CCK-4 for reducing the alcohol withdrawal syndrome.