ИСТИНА

This report summarizes the results of our long time work in the field of 3,7-diazabicyclo[3.3.1]nonane’s (bispidine) chemistry [1] and points out novel directions of research for the future [2-4]. In the first part of the lecture the current achievements and known features of this type of ligands are discussed including the possibility of bispidines to form supramolecular polymers both in crystals and in gel-phase. The comprehensive knowledge about structure and methodology of investigation of supramolecular gels and metallogels will be presented. In the second part we will discuss the ways of the possible application of bispidines and their complexes as bioactive compounds [2-4]. The radiation therapy is one of the modern and useful methods for the treatment of the oncological diseases, particularly, for the brain, head and neck tumors as well as for the tumors of some other localization. The problem of short decay time can be solved by use of new radiopharmaceuticals containing long-lived isotopes, particularly, 64Cu. To do this, the elaboration of easily modified ligand systems with high affinity to the metal cation and with wide possibilities of chemical modifications including the conjugation to the biological vectors is proposed.