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Pyrrolo[3,2-c]quinoline and its derivatives have interesting physicochemical properties and a wide spectrum of biological effects. In particular, it is the pharmacophoric fragment of the isocryptolepine alkaloid, which is currently obtained by various methods. We have proposed a simple and effective procedure for the synthesis of pyrrolo[3,2-c]quinoline structures based on the Fischer reaction. We have shown in numerous examples that the Fischer reaction can be successfully used for the synthesis of 2,3-disubstituted pyrrolo[3,2-c]quinolines. Based on the indolo[3,2-c]quinolines obtained by the Fisher reaction, we have proposed and implemented an original approach to the synthesis of isocryptolepine – the alkaloid, which has anticancer and antimalarial activity [2], and its benzannelated analogs.