ИСТИНА

Our study is focused on a novel approach to design hybrid metal-based physiologically active compounds with opposed modes of action – prooxidant metal center and antioxidant 2,6-dialkylphenol group. The synthesis and anti/prooxidant activity and cytotoxicity studies of novel organometallic/coordination compounds based on either biogenic metals (Fe, Mn, Co, Cu, Zn, Ni) or exogenic metals (Sn, Au) are presented and discussed. The multifactor antiproliferative and antioxidative activities assay of novel compounds has been performed by using DPPH, CUPRAC-tests, and enzymatic methods (lipoxygenase, gluthathione reductase, thioredoxine reductase, tubulin); ex vivo lipid peroxidation in mitochondria isolated from rat brain and liver. The in vivo study was performed for the hit compounds.