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RAMAN DIAGNOSTICS OF POROUS SILICON NANOPARTICLES UPTAKE AND BIODEGRADATION IN CANCER CELLS доклад на конференции
- Авторы: OSMINKINA L.A., TOLSTIK E., SIVAKOV V., TIMOSHENKO V.Yu, TSURIKOV K.E., HEINTZMANN R., POPP J., MATTHÄUS C.
- Международная Конференция : 10th International Conference "Porous Semiconductors - Science and Technology" PSST 2016
- Даты проведения конференции: 6-11 марта 2016
- Дата доклада: 9 марта 2016
- Тип доклада: Устный
- Докладчик: OSMINKINA L.A.
- Место проведения: Таррагона, Spain
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Аннотация доклада:
Raman micro-spectroscopy was used for diagnostics of uptake and biodegradation of porous silicon nanoparticles (SiNPs) in breast cancer cells (MCF-7 cell line) in-vitro. Two types of SiNPs, with and without photoluminescence in the visible spectral range, were investigated. The spatial distribution of photoluminescent SiNPs within the cells obtained by Raman imaging was verified by high-resolution structured-illumination optical microscopy (HR-SIM). Nearly complete biodegradation of SiNPs inside the living cells was observed after 13 days of the incubation. The results reveal new prospects of multi-modal visualization of SiNPs inside cancer cells for theranostic applications.
- Добавил в систему: Осминкина Любовь Андреевна