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Skolkovo Institute of Science and Technology, Moscow, Russia An informative assessment of probabilistic prognosis definition as an innovative estimation of human intelligence method to be interested for a wide range of scientific researches. The success of solving tasks in situations with varying probability of events and the structure of their relationship determines the human life quality and safety ultimately. As the basic research methodology was used a computer version of the new psychological original methodology “Prognosis 1, 2.5” developed for healthy adult subjects for integrative brain activity assessment. This approach is based on a commonly used in psychology method of "game of guessing.” It is based on testing subject to determine the different symbols orders in three different structure sets by predicting both and of symbols. The "Prognosis 2.5" method is widely used to assess of psychophysiological man status in different situations.