ИСТИНА

An ideal material for regeneration of bone tissue in reconstructive and corrective surgery and orthopedics, needs to be porous in order to allow the growth of blood vessels, nerve tissue and bone cells proliferation. Such materials compensating for the lost area of bone tissue should create necessary conditions for its regeneration. In this study, we are obtaining porous resorbable ceramic materials based on calcium magnesium phosphates. According to the laser granulometry of calcium magnesium phosphate, the nanoparticle are suitable for 3D printing where they have a dark gray color, due to the presence of decomposition products of ammonium acetate. The resulting composite (monomers/powder) structures in the form of a Kelvin structure were exposed to a temperature of up to 1200°C. The study of the metabolic activity of cells in the presence of extracts from the material showed that the materials are able to support the adhesion, spreading and proliferative activity of human mesenchymal stem cells. These samples of biomaterials are biocompatible and do not have a cytotoxic effect on mammalian cells. The resulting ceramic materials are suitable for the creation of resorbable bone implants, including individually designed inorganics bases for the treatment of bone defects. Acknowledgement: This work was supported by the RFBR, grant nos. 18-29-11079, 18-53-00034.