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This report presents the results of optimizing the transmutation process with the ultimate goal of bringing them to the pre-industrial level. When solving such problems, a more fundamental study of factors that lead to the possibility of transmutation and which impede this process is necessary. We have previously shown that biological culture, which is put on the brink of survival by the absence of a number of nutrients in the nutrient medium and nonspecific growth conditions, synthesizes the chemical elements necessary for the growth of new cells. This process is based on nuclear reactions involving, as a rule, the elements present in the liquid nutrient medium on the basis of conventional water or deuterium. To achieve control of the transmutation effect, it is necessary to solve as purely biochemical, as nuclear problems. In our experiments, we have used fast-growing syntrophic associations resistant to various toxicants, i.e. communities, in which there are more than three thousand different types of microorganisms, protozoa, bacteria and fungi. From biomass, micro- and macro-elements were maximally desorbed, and in nutrient media, a rational change was made in the composition of biogenic elements.