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Several of CLE peptides are known to be involved in vascular tissue development. It is also well known that auxin distribution cause initiation of the plant vascular tissue development. Instead of knowledge about involvement of reactive oxygen species (ROS) in root growth, it is not so clear about ROSes role in the vascular tissue development. We have observed that typical nitrotetrazolium blue (NBT) staining occurs not only in the root apical meristem as it was mentioned, but in vascular tissues as well. Secondly, we have found that CLE-like chemically synthesized dodecapeptide CLV3p do affect ROS distribution. Thirdly, peptides do affect PINs distribution. We suggest that CLE-like dodecapeptides can be the trigger and signal molecular that affect auxin transporters redistribution, auxin flow and ROS generation that is involved in plant vascular development as well. It is a great challenge to elucidate the questions: do peptides directly affect transporters, NADPH-oxidases or peroxidases. We are working on the molecular connections between peptides, ROSes and auxin redistribution.