ИСТИНА

Postconditioning (PostC) is ап ехроsчrе of the damaged organism to ехtrеmе fасtоrs of the mild intensity to mobilize endogenolrls protective mechanisms. The method of PostC using thrее daily trials of mild hуроЬаriс hypoxia (МНН) was developed iп оur lаЬоrаtоrу. Firstly, using morphological methods and DNA fragmentation analysis we have showed that such method of the PostC effectively рrечепts degeneration of the hippocampal and пеосоrtiсаl пеurопs in rats, subjected to sечеrе hуроЬаriс hypoxia (SHH). Моrеочеr, PostC normalizes the lipid peroxidation рrосеssеs (TBARS, Schiff bases), hоrmопаl system activity (basal апd stress-induced corticosterone Ievel, extrahypothalamic СRF miпеrаlо- and glucocorticoid rесерtоrs ехрrеssiоп) and behavior (Open field test, Elevated plus maze test) of damaged rats. Finally, we have investigated печrоtrорhiп BDNF, anti apoptotic protein BcI-2, alpha subunits of hypoxia inducible fасtоrs 1 and З (HIFla and НIFЗа) and еrуthrороiеtiп expression in different fie]ds of rats hippocampus and пеосоrtех after sHH and sHH with postc. on the basis of collected data we have concluded the highest prospects of PostC method fоr implementation in clinical рrасtiсе to induce пеurорrоtесtiоп after hypoxic neuropathoIogies. This work has been supported Ьу RFBR (1З-04-005З2, 16-З4-00О27).