ИСТИНА |
Войти в систему Регистрация |
|
ИПМех РАН |
||
Serotonin Reuptake inhibitor fluvoxamine is a drug approved for use during pregnancy. The effect of this substance is based on an increase in the content of serotonin in the synaptic cleft and prolongation of its actions. Fluvoxamine penetrates the placental barrier and not only to the maternal organism, but also to the fetus. In a large number of studies, it has been shown that serotonin in early embryogenesis serves as a trophic factor and contributes to the normal formation of various organ systems, including the circulatory and nervous systems. It monitors the proper neurogenesis and stimulates the myelination of nerve fibers, as well as regulates the functioning of mediator systems, such as dopaminergic, noradrenalinergic. Therefore, any intervention in the serotonergic system can lead to irreversible developmental disorders, and can also reduce the level of cognitive abilities and learning opportunities.