ИСТИНА

Previously we have used linearized somatic growth plots in mono- and bilogarithmic coordinates, in order to localize three transitions: infantile, juvenile and pubertal. Moreover, we have suggested that especially juvenile transition may be related in both genders to metamorphosis-like event, more close to the inversion of mortality trend that marks the principal transformation from development to aging. (Methods and Results) In addition, evaluation of relative morbidity and mortality has allowed us to differentiate the groups of diseases, characteristic to intermediate age categories and to senescence. We have suggested also that programming / imprinting and embedding phenomena occur before and after infantile transition respectively. Finally, we have offered to elaborate onto-and phylopathogenic models that describe the transfer of disease risk along the age scale in the individual ontogeny and across generations. (Conclusion) In conclusion, life-course periodization proved to be quite useful for constructing theoretical models that can be employed, e.g. to establish the role of stress hormones and proteins in onto- and phylogenetic bioregulation, as well as for considering the importance of sequential limitation of cell proliferation during the ontogenetic transitions revealed.