ИСТИНА

Aptamers are promising molecules for therapy and diagnostics. DNA-made aptamers combine high specificity of monoclonal antibodies with low immune response and ease of production[1]. However despite of all possible advantages aptamers did not gain adequate distribution. One of limiting reasons is complicated process of aptamers tuning.. Knowledge of aptamer's structure is crucial for succesfull optimiziations but due to nature of SELEX pipeline (method for obtaining aptamers) it is usually unknown Here we try to use computational approaches to overcome typical SELEX limitations and design G-quadruplex containing aptamers due to their increased stability compared to duplex analogs.