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Systemically active NGF mimetic increases the survival of pancreatic β-cells and attenuates the insulin resistance on the streptozotocine-induced diabetes 2 type on Wistar ratsдоклад на конференции
- Автор: Ivanov S.
- Международная Конференция : World Conference on Diabetes, Endocrinology & Neuropharmacology
- Даты проведения конференции: 3-4 июня 2019
- Дата доклада: 3 июня 2019
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: Лондон, United Kingdom
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Аннотация доклада:
Using the highly-specifc immunohistochemical method with anti-insulin antibodies, we succeeded to shown that while STZ causes a decrease in the β-cells number and a disturbances of their morphological structure, GK-2 eliminates these changes. Strong correlation between the morphometry indicators and the glucose blood level was revealed. Non-treated diabetic animals demonstrated the lack of pronounced decrease in glucose blood level caused by insulin (0.4 IU/kg), while GK-2 prophylactic course restored the response to insulin, thus demonstrating the attenuation of insulin resistance.
- Добавил в систему: Иванов Сергей Витальевич