ИСТИНА

CLU CC (rs11136000) genotype is associated with risk of Alzheimer’s disease (AD) (Harold et al., 2009; Lambert et al., 2009; Golenkina et al., 2010). The mechanisms by which this variant confers AD susceptibility remain largely unknown. Herein we describe how CLU CC genotype impacts brain neurophysiology during normal aging. The results imply that the genotype is related to the preclinical dysregulation of hippocampal networks and to the decreased cognitive networks efficiency during cognitive tasks. These factors may contribute causally to the pathogenesis of AD.