ИСТИНА

Nanodiamonds (NDs) are a very promising material for biomedicine. They are known for the high sorption properties that are related with complex multifunctional surface. Such properties allow using NDs as a base for drug delivery. Nowadays there is a problem of developing methods of controlling fluorescent and sorption properties of NDs for creating a multipurpose material on the base of them. This material would be able to be both: a fluorescent marker and a drug deliverer in a living body. That is why the investigation of the mechanisms of interactions of NDs with biomolecules, especially with the ones that can be found in cells, is very important. In this study adsorption properties of carboxylated NDs with 10 nm size to complimentary nitrogenous bases pairs in water were investigated. It was found that no destruction of pairs occurs during adsorption. Adsorption properties of detonation ND with 5 nm and 10 nm sizes and of ND with NV-centers to DNA were studied. Mechanism of adsorption DNA to ND was determined. The influence of the interactions between NDs and DNA in water on fluorescence of NDs was detected. A correlation between adsorption activity and changes in the intensity of fluorescence was found. The explanation of difference in changes of fluorescence for different NDs was proposed. Investigations were carried out by methods of laser Raman and IR spectroscopy. This work was supported by grant no.16-32-00882 mol_a of the Russian Foundation for Basic Research.