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Internal water oceans on planets and planetary satellites are considered as likely ‘shelters’ of a microbial life that could spontaneously origin in the Solar System. Widespread in the Universe three-atomic molecules of HCN and H2O and derivative from them formamide (NH2COH) could be initial blocks for the primitive terrestrial and extraterrestrial life forms. As shown recently in laboratory experiments (JINR, Dubna, Russia), irradiation of formamide by protons in the presence of mineral or meteoritic catalyzers leads to synchronous synthesis of a wide range of prebiotic compounds (amino acids, heterocycles, alcohols, amides, sugars, etc.) po-tentially relevant to develop genetics (based on RNA and DNA) and metabolism underlying the terrestrial life. As suspected, proton irradiation of formamide creates active radicals stimulating effectively a further synthe-sis. Noteworthy, such types of synthesis are abiotic and run in the same chemical environments. Finds of possible fossilized pseudomorphic microbial structures in carbonaceous chondrites having an extremely high age ~4.5-4.6 Gyr points likely to origin of microbial life before the formation of Earth. Here we outline processes that could create appropriate conditions for biological synthesis at the very beginning of our planetary system formation.