ИСТИНА

Metals are important elements to participate in biosystems life. However, some metals in terms of security are considered to be toxic to the organism. After contact, even in small doses in drinking water, blood, and other body fluids, they can disrupt normal physiological processes. Especially it should be noted that a large number of chemicals containing various metal ions are used in medicine. Recently, it has been found that the presence of metal ions, especially heavy metals ions, in water solutions containing protein molecules are capable to form clusters [1]. Moreover, the physicochemical properties of fluids affect on sizes and mobility of protein molecular clusters. This process from the medicine standpoint is often a symptom of many human diseases. Considering the above facts, in terms of experimental molecular optics and spectroscopy, this work is associated with the study of molecular motion nature and intermolecular interactions in water solutions of biological macromolecules under the action of iron ions. Ferric chloride (III) was selected as the substance containing iron ions. Relevance of the work settles the fact that on an industrial scale this substance is used as a coagulant for water purification. Its particles remain in water and enter the bloodstream through the stomach lining. One of the metal carriers is in blood is albumin that’s why it is interesting to investigate its behavior in presence of ferric ions. As a result of the work was investigated the occurrence of ferric chloride clusters in albumin water solutions containing ferric ions (III) and was studied albumin molecules molecular mobility in water solution and while adding a ferric chloride (III). It was observed very interesting result: Serum albumin dynamic parameters investigation in solutions with adding iron ions (III) have shown that macromolecules hydrodynamic radius of scattering particles increasing very weakly, but weight of the particles while adding ferric chloride (III) rise in about one order. Scattering particles in Albumin solution were found molecular weight increasing while adding iron chloride (III), which can be caused by aggregation of iron chloride ions in completely forms as a result of interaction with water. It was revealed that the cluster formation process while adding iron chloride (III) to the water solution of BSA is not found. Based on the above findings, there is a slight effect of iron chloride (III) on serum albumin molecular mobility and it can be the safety use iron chloride (III) as a coagulate for water treatment. [1] Marjolaine Roche, Philippe Rondeau, Nihar Ranjan Singh, Evelyne Tarnus, Emmanuel Bourdon “The antioxidant properties of serum albumin” // FEBS Letters 582(13), 2008. France. P. 1783–1787