ИСТИНА

As a result of the preparatory work, it was revealed that the ions of calcium, zinc, magnesium and chromium do not significantly affect the collagen and collagenase molecules in buffer solutions separately. The obtained pH dependences of the translational diffusion coefficient Dt and hydrodynamic radius Rh for the molecules under study have a nonlinear form (close to parabolic) with minimum and maximum at the isoelectric point, respectively (pI 6.0). Based on the results obtained, it can be concluded that chromium ions really strengthen the collagen structure, and the rate of breakdown of protein molecules is reduced by 70%. The reaction rate can be increased by adding calcium or magnesium ions to the solutions. However, the rate of biodegradation of collagen fibers that is observed in a pure solution is still not observed. The maximum rate of breakdown of protein molecules is achieved by the activation of collagenase by Ca2+ ions.