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A very long chain fatty acid (VLCFA) is a fatty acid with 22 or more carbons. Their biosynthesis occurs in the endoplasmic reticulum. VLCFA’s can represent up to a few percent of the total fatty acid content of a cell. Unlike most fatty acids, VLCFA’s are too long to be metabolized in the mitochondria, and must be metabolized in peroxisomes. Certain peroxisome disorders can be associated with an accumulation of VLCFAs