ИСТИНА

Dialdehyde polysaccharides are successfully used all over the world for the addition of amines, peptides and enzymes. However, the problem of reducing toxicity is especially acute not only for substances of a peptide nature, but also for containing reactive aldehyde groups. These include the cotton toxin gossypol - naphthaldehyde with a wide range of physiological activity. The main question remains whether dialdehyde polysaccharides are suitable for use as carriers of substances of naphthaldehyde nature Two groups of gossypol-containing physiologically active polymers based on dialdehyde dextran and dialdehyde carboxymethylcellulose with different molecular weights, number of oxidized units and content of gossypol, have been synthesized and characterized. The main sites of covalent binding of gossypol with macromolecules of dialdehyde polysaccharides have been established. It was found that during the hydrolysis of polymer derivatives under conditions simulating physiological free gossypol is not released. The hydrolysis products contain naphthoquinones with eliminated aldehyde and isopropyl groups, as well as products of their further oxidation. Thus, using the example of polymer derivatives of gossypol covalently bound to dialdehyde polysaccharides, it was shown that the Ringsdorf model is not universal and does not work in the case of using dialdehyde polysaccharides as carriers of aromatic aldehydes. The effect of a significant decrease in toxicity in vitro was found with the covalent binding of gossypol to carrier polymers. The synthesized polymers can be recommended for further research as promising antiviral drugs.