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There is steadily growing interest in the synthesis of complex copolymer microgels with a specific affinity to nanoparticles, biopolymers or drugs. Ones of the key challenges during polymerisation process are how to control spatial distribution of different comonomers in the microgels and how does the spatial distribution of comonomers influence on microgel swelling behaviour, internal structure, interaction with guest molecules and etc. In the present study we have investigated the properties of microgels with random and block copolymer morphologies using a coarse-grained model with a molecular simulation techniques (DPD and MD).