ИСТИНА

Telomerase is a key participant of telomere length maintaining system. Using yeast model system we were able to find how telomerese itself can control the telomere length and determine the telomere to be elongated first. Further study resulted in understanding the role of specific telomere binding protein in telomere length regulation. STructurue of N-terminal domain and nucleic acids interaction sites determined by NMR will be discussed. In mammals telomerase is activated in cancer. The novel approaches to design telomerase inhibitors - small molecule and oligonucleotide-based will be discussed. Besides being an essential part of telomerase complex telomerase RNA has other function unrelated to telomerase. The data about unusual function of telomerase RNA will be presented.