ИСТИНА

Activity at rest provides valuable information about functional organization of brain networks. However, lack of cellular resolution in human brain imaging techniques precludes analysis of some of the key properties of resting state networks. Here we used a large-scale c-Fos imaging of resting state neuronal activity in the mouse brain combined with graph analysis methods to get deeper insights into structure and functional significance of resting state brain networks. We compared experimentally identified networks with model networks having the same parameters of edges and nodes: random, scale free and small world networks, using parameters of clustering and global efficiency. Clustering of experimental networks was at the same level as in scale free network – the number of clusters in experimental networks exceeded the random level. However, global efficiency analysis revealed that these clusters have weak interactions with each other or even no interaction at all – thus the global efficiency of experimental networks was at the same level as of a random network. We also found that a single strong traumatic experience can lead to global and long-term changes in the structure of resting state networks. The resting state network of mice which underwent traumatic experience had greater entropy than that of naive mice, especially in the zone of increased influence of strong correlations. We suggest that these changes reflect replay of neuronal assemblies involved in the states of past experience