ИСТИНА

In this work monomers of polyethylene glycol derivatives, such as PEG-methacrylate or PEGMA (Mw=350 Da) and PEG-diacrylate or PEGDA (Mw=575 Da), were chosen, due to its good biological properties, ability to degrade in body environment, commercial availability, and applicable for DLP printing. These monomers are liquids at room temperature and have a good solubility in water. Pre-synthesized calcium phosphate (tricalcium phosphate (Са3(РО4)2, TCP), brushite or dicalcium phosphate dihydrate (СаНРО4•2Н2О, DCD), octacalcium phosphate (Са8(НРО4)2(РО4)4•5Н2О, OCP)) were used for filling hydrogel. Hydrogels and filled composites were obtained by photopolymerization reaction with photoinitiator Irgacure®819. Mixing of all components was performed on a magnetic stirrer for 10 minutes, after which photopolymerization was performed under a household UV lamp and samples with the gyroid structure were obtained at DLP 3D-printer Ember (Autodesk, USA).The combination of composites unique properties makes them perspective for further biomedical evaluation as elastic bioimplants for bone tissue recovery. This work was supported by the Russian Science Foundation (project № 19-19-00587).