ИСТИНА

The aim of this study: To evaluate the levels of oxidative and carbonyl stresses indicators and their relationship with early renal damage markers (podocalyxin and β2-macroglobulin), in comparable by most characteristics (standardized) groups of healthy men and patients with type 1 diabetes mellitus (with albuminuria different levels). Сonclusion Regardless of the level of albuminuria, men with T1DM had increased podocalixin, indicating the glomerular kidney apparatus damage. These patients have significantly increased levels of lipids, proteins and DNA oxidative damage parameters, as well as close relationships between these parameters. These abnormalities also apply to stage A1, when renal function pronounced changes not detected. This study data proved the oxidative and carbonyl stress important role in kidney damage pathogenesis in the disease early stages, which can be used for the diabetic nephropathy prevention and early treatment development