ИСТИНА

One of the serious, life-threatening complications of hormonal stimulation during in vitro fertilization (IVF) is ovarian hyperstimulation syndrome (OHSS). There is no generally accepted understanding of the onset and development of OHSS in the literature. Existing models of OHSS pathophysiology do not allow preventing the occurrence of OHSS and developing an effective therapy for it. The aim of this work was to develop a new pathophysiological model of the onset and development of OHSS, which made it possible to: 1) explain the need for the injection of the hCG trigger to trigger OHSS; 2) explain the accumulation of fluid in the abdominal cavity (ascites) in OHSS; 3) predict an effective strategy for the prevention and non-symptomatic treatment of OHSS. Analysis of the literature data allowed us to make the assumption that the central role in the development of OHSS is played by such a biophysical parameter as the transmembrane potential of ovarian cells. As a result, a completely new model of the emergence and development of OHSS was developed, which linked together all the literature data on OHSS and made it possible to propose a new strategy for the emergence and development of OHSS, based on the stabilization of the transmembrane potential of cells. The proposed strategy for the therapy and prevention of OHSS has been tested in more than 10,000 IVF patients and has been shown to be effective.