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One of the most important medical and socially significant problems in the world is the treatment and rehabilitation of patients with severe brain damage who are in a chronic critical condition. The consequences of severe traumatic brain injuries and acute disorders of cerebral circulation, operated neoplasms, as well as anoxic brain lesions inevitably lead to prolonged passive bed rest, persistent inability to self-care. As it is known, patients in a chronic critical condition due to severe brain damage are at high risk of decubitus ulcers, since they have a combination of predisposing factors: on the one hand, pronounced disorders of consciousness and persistent neurological deficit; on the other hand, constantly high pressure on the integumentary tissues, displacement, friction, high humidity, microcirculation disorders and limitations of the patient's mobility. The incidence of decubitus ulcers in hospitals is still high. Decubitus ulcers in patients in a chronic critical condition are poorly treatable, often worsen or relapse, which significantly limits and slows down rehabilitation measures, increases the duration of the patient's stay in the hospital, and contributes to the development of septic complications. As part of the new scientific and clinical direction - "invasive rehabilitation of patients in need of prosthetics of vital functions", the Federal Scientific and Clinical Center for Resuscitation and Rehabilitation has developed a number of conservative and minimally invasive surgical techniques for the treatment of Decubitus ulcers in patients in chronic critical condition: Nutritional status correction programs; stimulating techniques (laser technologies, electrical technologies), biostimulating techniques (compositions based on fibrin complex), surgical methods.