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Micromycetes of the Aspergillus genus are known as producers of extracellular proteases with different activities, including activities against proteins of the hemostatic system. This enables the potential application of these enzymes in diagnosis and disease treatment. Therefore, further investigations of the Aspergillus proteases is required. Here, we studied the effect of micromycetes A. flavus 1, A. ochraceus L-1 and A. terreus 2 proteases on proteins of the hemostatic system.