ИСТИНА

Chromatographic method development remains a relatively time- and labor-intensive activity. Investment in systematic processes (i.e. Quality by Design processes) has improved the quality and efficiency of method development projects. But such processes still require significant repetitive labor: setting up experiments to cover the design space, processing chromatograms, tracking peaks, and comparing runs to find optimal conditions. Productivity can be improved by automating these tasks. Method development software can automatically generate lists of experiments to cover a user-defined design space, communicate with chromatography data systems (CDSs) to run those experiments, and perform some automated processing for subsequent review. Here, we present a new automated workflow in the method development software AutoChrom®, featuring targeted MS based peak tracking for more efficient processing.