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Intensity of interaction of location of manufacturing of individual country and evolution of the global economy in recent decades has greatly increased due to profound changes in the global economy. The second wave of globalization since 1970 has included not only the integration of markets for goods and factors of production, but also the internationalization of production (includ-ing rise of trade in tasks, offshoring, intraindustry trade etc.). Changing location of the manufactur-ing, in turn, influences the country's position in international division of labor (IDL), as the country takes part in IDL not as a point, but as a set of spatial systems of different hierarchical levels. The purpose of this article is twofold: on the one hand, to investigare the nature (intensity, structure, trends, consequences) of the interaction of the location of U.S. manufacturing and the transformation of the global economy, and on the other, to use the case of the U.S. to test some ana-lytical approaches applicable to other countries. U.S. domestic market potential causes relatively low involvement of this country in the international division of labor. If the impact of global economic processes is essential for the location of American manufacturing, the more it is true for countries most actively involved in IDL.