ИСТИНА

Plant polysaccharides, having a broad set of practically useful physical, chemical and technological properties, as well as its own biological activity, are promising to modify the properties of known physiologically active substances. In recent years, based on polysaccharides have developed so called Drug Delivery Systems (DDS). This paper deals with the development of DDS based on the known anthelmintic drugs (medamin, albendazole, fenbendazole, fenasal, azinoxe) with the involvement of following polysaccharides- pectin, arabinogalactan, hydroxiethystarch (HES) etc. The resulting new anthelmintic drugs had not only increased activity against nematodes, but also showed a new range of action against Echinococcus.. For this technology was used the way of mechanochemical modification of poor soluble substances with water-soluble polymers. It is known that substances of a.m.drugs are poor soluble or not soluble in water and physiologically active solutions (for example, gastric juice). Taking into the consideration that the activity of drugs is largely determined by their solubility and bioavailability, we have been tasked to increase the water solubility of these drugs in highly stressed joint machining of substances and various types of polymers (polysaccharides, synthetic and plant polymers). In this case, products were obtained, which are called as supramolecular complexes. These complexes have not only considerably increased water solubility and dispersion (formation of nano-sized particles) but higher anthelmintic activity as compared with known preparations. In addition, newly obtained complex (“Medapec” by name) has a new type of activity – it can be used against Echinococcosis granulosis when tested in vivo. Such properties of this complex suggest the formation of nano-sized anthelmintic DDS. This technology of mechanochemical modification of anthelmintic drugs is universal and acceptable to search of effective drugs in a number of other organic compounds with poor water solubility (for example, cancer drugs etc.).