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World potato crop losses from fungal, viral, bacterial, and many other types of diseases account for about 90 million tons or 17% of gross collection. To control the level of fungal, bacterial, and other infections in crops of potatoes and storage after harvest must be rational use of chemical and biological methods of protection [1]. And so, should be considered highly relevant research on the development of efficient, environmentally friendly multi-purpose protection of potato pests and diseases during the growing season and storage [2]. We propose a method of producing such a promising preparations of protection in the form of multi-component compositions based on the use of mechanochemistry methods, namely, by machining the joint acting formulations known substances with water-soluble polymers [3]. As preparations were selected tebuconazole carbendazim, thiuram and others. The auxiliary substances for modifying the properties of preparations were used carboxymethyl cellulose derivatives, arabinogalactan, hydroxyethyl starch, PVP et al. These compositions thus have a high biological activity, namely: - developed by us on the basis of Carbendazim preparations showed high effectiveness against rot and Rhizoctonia potato storage; - compositions reduced weight percentage of patients with dry rot of tubers in 3,0-14,5 times compared to the control, as compared with the standard drug (Colfugo-Super, SC) biological efficiency was higher on average by 25-26%. - preparations had a positive impact on the biometric characteristics of plants and crop yields. The highest productivity was observed in potato plants by using a silica compositions Carbendazim and sodium carboxymethylcellulose. With this increase in yield compared with the control was 35% at the autumn etching and 57% for the treatment of tubers spring.