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Study of distribution and evolution of restriction-modification systems with restriction endonuclease of the AlwI familyдоклад на конференции
- Авторы: Makarikova O., Popova A., Alexeevski A.
- Международная Конференция : «Биоинформатика и системная биология регуляции и структуры геномов» BGRS/SB-2022
- Даты проведения конференции: 4-8 июля 2022
- Дата доклада: 6 июля 2022
- Тип доклада: Стендовый
- Докладчик: Makarikova O.
- Место проведения: Новосибирск, Russia
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Аннотация доклада:
Restriction-modification (R-M) is the defense system of prokaryotes against phage and plasmid infection. The system has two enzymatic activities: restriction endonuclease (RE) and methyltransferase (MTase). The former hydrolyzes invaded DNA within or near their recognition site whereas the latter prevents self degradation of the cell genome by methylation of the recognition site. The system type II REs of the AlwI family represented in Pfam by the RE_AlwI domain are promised for bioengineering usage as nickases. The aim of this work is to study the distribution and evolution (horizontal gene transfer) of R-M systems containing proteins of the family.
- Добавил в систему: Макарикова Ольга Леонидовна