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Correlative Biomarkers for CART19 Response in Patients with Relapsed or Refractory Diffuse Large B-Cell lymphomaдоклад на конференции
- Авторы: Batlevi Connie L., Nos Grigorii, Kotlov Nikita, Sorokina Maria, Okwali Michelle, Bagaev Alexander, Michaud Laure, Shah Gunjan, Shuoval Roni, Tomas Ana Alarcon, Ewalt Mark, Belova Ekaterina, Degryse Sandrine, Tasearslan Cagdas, Podsvirova Svetlana, Love Anna, Postovalova Ekaterina, Fowler Nathan, Perales Miguel-Angel, Schoder Heiko, Dogan Ahmet, Arcila Maria E., Salles Gilles, Sauter Craig
- Международная Конференция : ASH 2022
- Даты проведения конференции: 8-11 декабря 2022
- Дата доклада: 10 декабря 2022
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: United States
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Аннотация доклада:
Integrated molecular analysis of the LME and genomic alterations provides valuable information about correlative biomarkers for response to CART19 immunotherapy in DLBCL patients. With this cohort, PIK3CA amplification corresponded to improved PFS in DLBCL. We observed increased MHCII expression and centrocyte-like cells in GCB DLBCL CART19 responders, while SMAD1 was higher in ABC responders. Germinal center-like and mesenchymal LME exhibited increased OS, while inflamed and depleted LME subtypes had decreased OS. These genomic biomarkers for CART19 treatment response may help guide clinical treatment plans, minimize adverse events, or develop new therapeutic approaches.
- Добавил в систему: Сорокина Мария Андреевна