ИСТИНА

Drug delivery systems based on polymeric materials play a significant role in improving the pharmacological and therapeutic properties of drugs by controlling their pharmacokinetics, biodistribution, and toxicity. Among the wide range of biocompatible and biodegradable polymers used to develop drug delivery systems, biopolyesters and polyamic acids are promising candidates for encapsulating hydrophobic drugs. The paper presents the synthesis of a polylactic acid-ε-polylysine graft copolymer using pulsed mechanochemical effects implemented under the conditions: type 1 - rheological explosion and type 2 - reaction mixing in a vibrating mill, with varying the initial ratio of homopolymers. The structure and properties of the resulting copolymer were characterized by IR spectroscopy, 1H NMR, and dynamic light scattering. The yields of the copolymer were estimated depending on the type of treatment. The effect of a filler in the form of elemental boron nanoparticles, in the size range of 5–15 nm [1, 2], on the properties and yield of a polylactic acid-ε-polylysine copolymer was studied.