ИСТИНА

The aim of this study was to synthesize and evaluate Pt (IV) prodrugs, as well as Ru(II) and Ru(III) compounds with organic ligands based on phenosanic acid. The introduction of this antioxidant moiety has the potential to soften the toxic effects of the compounds on healthy cells. The obtained compounds were fully characterized using NMR spectroscopy, mass spectrometry, and elemental analysis. The in vitro antiproliferative activity of the compounds was assessed using the MTT assay on A549, MCF7, HCT116, and WI38 cell lines. The platinum complexes exhibited superior activity compared to the reference compound cisplatin. The ruthenium compounds demonstrate activity within the micromolar concentration range. The ability of several compounds to induce apoptosis was studied.