ИСТИНА

Efficient approach is proposed for the study of electrode reactions of insoluble or sparingly soluble compounds in aqueous media consisted in their solubilization with polymer particles of a micellar type. Amphiphilic copolymers of N-vinylpyrrolidone with triethylene glycol dimethacrylate were used as solubilising agents. They exhibited already good efficiency at creating of water soluble forms of zinc tetraphenylporphyrinate (ZnTPP) [1, 2]. Nanostructures containing ZnTPP as an electrochemical marker were studied in aqueous and aqueous-organic media by cyclic and differential pulse voltammetry on solid electrodes (Au, Pt, glassy carbon), electron absorption spectroscopy and fluorescence. The hydrodynamic radii of nanostructures were determined by dynamic light scattering, and their size distribution dependence was stated on a copolymer concentration loaded with ZnTPP, the temperature and a solution composition. To take into account nanoparticles size distribution in neutral aqueous buffer solutions, a model of electrochemical transformations of nanoparticles was proposed considering the probability of non-adiabatic electron transfer. A dynamics of nanostructures destruction in MeCN and H2O – MeCN mixtures (10-50%) was studied spectroscopically, on the Soret absorption band, and on redox reactions of ZnTPP. The proposed approach could be promising to form water soluble forms of potential drugs based on lipophilic Ptiv complexes [3, 4].